BackgroundASP3026isaselectiveinhibitorofALKwithIC50valueof3.5nM[1].ASP3026isapotentALKinhibitorandhasadifferentselectivitywiththereportedALKinhibitorcrizotinib.Whentestedwithapanelof86tyrosinekinases,ASP3026showedthehighestselectivityforALK,ROSandACKkinases.InNCI-H2228NSCLCcellsexpressingEML4-ALK,five-daytreatmentofASP3026resultedinacellgrowthinhi...